Interferon Pathway Activation in Monogenic and Non-monogenic Forms of Pediatric SLE With Renal Involvement. Multicenter Observational Study of Biological Samples.
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Pediatric SLE includes monogenic forms, some of which involve the interferon type I (IFN-I) pathway. The IFN-I pathway is renally active in adult SLE and correlates with the extent of renal damage. In pediatric SLE, and particularly in lupus nephritis, activation of the IFN-I pathway has never been studied, nor is it known whether monogenic forms underlie more pronounced interferon activation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 month
Maximum Age: 17
Healthy Volunteers: f
View:
• Diagnosis of SLE arising before the age of majority (until the age of 18 years) according to SLICC and/or EULAR criteria 2019;
• Clinical, laboratory and/or histologic evidence of renal involvement manifested before the age of 18 years;
• Signature of informed consent.
Locations
Other Locations
Italy
Meyer Children's Hospital IRCCS
RECRUITING
Florence
IRCCS Gianna Gaslini
RECRUITING
Genova
IRCCS Humanitas Research Hospital
RECRUITING
Rozzano
Contact Information
Primary
Carmela Errichiello, MD
carmela.errichiello@meyer.it
055/5662563
Backup
Carmela Errichiello, MD
055/5662563
Time Frame
Start Date: 2023-06-07
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 60
Treatments
Other: Activation of interferon pathway
Assessment activation of interferon pathway on biological samples (blood and kidney biopsy) in cSLE patients
Related Therapeutic Areas
Sponsors
Leads: Meyer Children's Hospital IRCCS